It belongs to a class of drugs called tyrosine kinase inhibitors (TKIs). Here are the specific uses:
This is a type of kidney cancer. Votrient is used to treat patients with advanced RCC who have not received prior treatment.
This is a type of cancer that can develop in various tissues like muscles, fat, or blood vessels. Votrient is used to treat patients with advanced STS who have received prior chemotherapy and whose cancer has progressed.
Votrient works by targeting and blocking specific proteins called tyrosine kinases. These proteins play a crucial role in various cellular processes, including cell growth, division, and blood vessel formation. By blocking these proteins, Votrient can:
Starve tumors: It inhibits the development of new blood vessels within tumors, thereby limiting their blood supply and hindering their growth.
Slow cancer spread: It may interfere with the ability of cancer cells to migrate and form new tumors in other parts of the body.
We recommend that you take these tablets on an empty stomach. It’s important to swallow the tablets whole without crushing them, as crushing can alter how your body absorbs the medication. If you happen to miss a dose and there’s less than 12 hours until your next scheduled dose, you should skip the missed dose and just continue with your regular dosing schedule.
You are advised to take a daily dose of 800 mg, which means taking four 200 mg tablets at once, by mouth.
For patients with moderate hepatic impairment (total bilirubin > 1.5 to 3 × ULN and any ALT value), the recommended dose is 200 mg once daily.
For patients taking strong CYP3A4 inhibitors (e.g., ketoconazole, ritonavir, clarithromycin), the dose should be reduced to 400 mg once daily.
For patients unable to tolerate the initial dose reduction, the dose may be further reduced to 200 mg once daily, and if this is not tolerated, VOTRIENT should be permanently discontinued
When taking Votrient tablets, it’s crucial for you to be aware of certain warnings and precautions to ensure your safety:
Do not take Votrient if you have severe liver disease. Pazopanib, the active ingredient, can lead to severe or even life-threatening liver issues. We’ll need to perform regular blood tests to monitor your liver function closely.
Immediately contact your doctor if you experience nausea, vomiting, pain in the upper stomach, loss of appetite, fatigue, easy bruising, dark-colored urine, or jaundice (a yellowing of your skin or eyes).
Votrient may reduce the blood cells that help your body fight infections and aid in clotting, increasing your risk of infections or making it easier for you to bleed. If you notice unusual bruising or bleeding, or if you have signs of an infection like fever, chills, or body aches, let your doctor know right away.
Liver, heart disease, heart rhythm issues, or long QT syndrome.
High blood pressure.
A history of blood clots or stroke.
Thyroid disorders.
Headaches, seizures, or vision problems.
Any perforation (hole or tear) or fistula (abnormal passageway) in your stomach or intestines.
Stomach or intestinal bleeding; or
Surgery in the last 7 days.
This straightforward guidance is designed to help you understand the precautions necessary for taking Votrient safely.
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